Home

from whence ye came

  Message

whats up?

  me

who is mineapple?

  art

self-explanatory

  commissions open!

want me to draw something for you?

  Art Blog

just the arty bits

 

Relief As Doctors Now Have Permanent Cure for Sickle Cell Anaemia - The Herald

flange5:

freestyleminded:

coffee-sweaters-tea-nursingmajor:

dookiediamonds:

guywithamohawk:

brownglucose:

Y E S ! ! ! ! ! ! ! ! ! ! ! !

!!!!!!!!!!!!!

YOOOOOOO!!!! THIS IS A MASSIVE FUCKING BREAKTHROUGH!!! BIG UPS TO SCIENCE YO!

GOOD LOOKING OUT CHEMIST!

🌹

From the University of Illinois-Chicago press release:

In the new procedure, patients receive immunosuppressive drugs just before the transplant, along with a very low dose of total body irradiation — a treatment much less harsh and with fewer potentially serious side effects than chemotherapy.

Next, donor cells from a healthy and tissue-matched sibling are transfused into the patient. Stem cells from the donor produce healthy new blood cells in the patient, eventually in sufficient quantity to eliminate symptoms. In many cases, sickle cells can no longer be detected. Patients must continue to take immunosuppressant drugs for at least a year.

Julius and Desmond Means were cured of sickle cell disease at UI Health through a chemotherapy-free stem cell transplant in 2013. Their older brother, Clifford (center), was the donor.

In the reported trial, the researchers transplanted 13 patients, 17 to 40 years of age, with a stem cell preparation from the blood of a tissue-matched sibling. Healthy sibling donor-candidates and patients were tested for human leukocyte antigen, a set of markers found on cells in the body. Ten of these HLA markers must match between the donor and the recipient for the transplant to have the best chance of evading rejection.

In a further advance of the NIH procedure, physicians at UI Health successfully transplanted two patients with cells from siblings who matched for HLA but had a different blood type.

In all 13 patients, the transplanted cells successfully took up residence in the marrow and produced healthy red blood cells. One patient who failed to follow the post-transplant therapy regimen reverted to the original sickle cell condition.

None of the patients experienced graft-versus-host disease, a condition where immune cells originating from the donor attack the recipient’s body.

One year after transplantation, the 12 successfully transplanted patients had normal hemoglobin concentrations in their blood and better cardiopulmonary function. They reported less pain and improved health and vitality.

Four of the patients were able to stop post-transplantation immunotherapy without transplant rejection or other complications.

“Adults with sickle cell disease can be cured without chemotherapy – the main barrier that has stood in the way for them for so long,” Rondelli said. “Our data provide more support that this therapy is safe and effective and prevents patients from living shortened lives, condemned to pain and progressive complications.”

Source